Quinolinic Acid increases Glutamate

QUIN increases Glutamate

5.2 ValidityScore

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Proofs

2017

Publications Review

Anti-inflammatory treatment for major depressive disorder: implications for patients with an elevated immune profile and non-responders to standard antidepressant therapy
Cristina M Moriguchi-Jeckel, Erik FJ de Vries, Hans C Klein, Janine Doorduin, Luis Eduardo Juárez-Orozco, Paula Kopschina Feltes, Rudi AJO Dierckx
« QUIN [Quinolinic acid] also increases glutamate release to neurotoxic levels, inducing oxidative and nitrosative stress (O&NS) in MDD.»
Strong Magnitude of Effect.
#Major depressive disorder, antidepressants, microglia, neuroinflammation, pro-inflammatory cytokines
ncbi.nlm.nih.gov/pmc/articles/PMC5606303
10.1177/0269881117711708

From this research we know that
5.0
Major depressive disorder increases Proinflammatory cytokines
6.0
Oxidative stress causes DNA damage
4.7
Phenylalanine hydroxylase decreases Serotonin
5.5
QUIN induces Nitrosative stress
5.0
Major depressive disorder increases IFN-γ
5.0
IL-6 increases Indoleamine 2,3-Dioxygenase
5.5
PGG2 converts to PGH2
5.2
QUIN increases Glutamate
4.2
COX-1 may increase Major depressive disorder
5.0
IL-1β increases Indoleamine 2,3-Dioxygenase
4.7
Phenylalanine hydroxylase decreases Noradrenaline
5.0
Tyrosine Hydroxylase decreases Dopamine
4.8
Major depressive disorder increases IL-1β
5.0
IL-2 increases Indoleamine 2,3-Dioxygenase
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Arginine converts to Nitric Oxide
5.5
Sirtuin regulates Neurogenesis
5.0
Tryptophan Hydroxylase-2 decreases Noradrenaline
5.0
Proinflammatory cytokines stimulate Nitric Oxide
5.0
Major depressive disorder increases TNF-α
5.2
QUIN increases ROS
5.3
Indoleamine 2,3-Dioxygenase produces QUIN
4.0
COX-2 may increase Major depressive disorder
5.0
TNF-α increases ACTH
4.8
Proinflammatory cytokines decrease BH4
5.5
Sirtuin regulates Mitochondrial function
4.8
Proinflammatory cytokines decrease Neurotransmitters
5.0
Depression decreases Coenzyme Q10
5.2
QUIN induces Oxidative stress
5.5
QUIN increases RNS
5.2
Nitrosative stress increases Inflammation
5.2
Nitrosative stress increases Protein oxidation
4.5
COX-1 may increase Neuron degeneration
5.5
Sirtuin regulates Circadian rhythm
5.5
Nitrosative stress increases Lipid peroxidation
5.0
TNF-α increases CRH
5.3
Indoleamine 2,3-Dioxygenase produces Kynurenic acid
5.0
Tryptophan Hydroxylase-2 decreases Dopamine
5.0
IL-6 increases Cortisol
4.8
Oxidative stress decreases Lipids
5.2
Nitrosative stress causes DNA damage
5.0
Tryptophan Hydroxylase-2 decreases Serotonin
5.0
Tyrosine Hydroxylase decreases Serotonin
5.0
Tyrosine Hydroxylase decreases Noradrenaline
4.7
Phenylalanine hydroxylase decreases Dopamine
5.0
Depression decreases PUFA
5.0
Depression decreases Zinc
5.0
Depression decreases Vitamin C
5.0
Depression decreases Vitamin E
5.0
Depression decreases Glutathione
5.0
Oxidative stress increases Inflammation
4.8
Oxidative stress decreases Proteins
5.0
TNF-α increases Indoleamine 2,3-Dioxygenase
5.0
NAD+ induces Sirtuin
4.8
Major depressive disorder decreases Tryptophan
5.0
Indoleamine 2,3-Dioxygenase produces NAD+
5.0
IL-1β reduces Serotonin
5.0
IFN-γ increases Indoleamine 2,3-Dioxygenase
5.0
TNF-α reduces Serotonin
5.0
IFN-γ reduces Serotonin
5.0
IL-6 reduces Serotonin
5.0
IL-2 reduces Serotonin
5.0
TNF-α increases Cortisol
5.0
IL-6 increases ACTH
5.0
IL-6 increases CRH
4.7
LPS increases Inflammation
5.0
Major depressive disorder increases IL-6
5.0
Major depressive disorder increases IL-18
5.0
Major depressive disorder increases CRP

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Modified by 1 week ago on Mar 17, 2023

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