Phenylalanine hydroxylase decreases Serotonin | BioMindmap.com

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Phenylalanine hydroxylase decreases Serotonin

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2017

Publications Review

Anti-inflammatory treatment for major depressive disorder: implications for patients with an elevated immune profile and non-responders to standard antidepressant therapy
Cristina M Moriguchi-Jeckel, Erik FJ de Vries, Hans C Klein, Janine Doorduin, Luis Eduardo Juárez-Orozco, Paula Kopschina Feltes, Rudi AJO Dierckx
«BH4 is an essential enzyme co-factor for phenylalanine hydroxylase, tryptophan hydroxylase[TPH2] and tyrosine hydroxylase[TH] which are rate-limiting enzymes for the synthesis of serotonin, dopamine and norepinephrine[Noradrenaline], respectively.»
Strong Magnitude of Effect.
#Major depressive disorder, antidepressants, microglia, neuroinflammation, pro-inflammatory cytokines
ncbi.nlm.nih.gov/pmc/articles/PMC5606303
10.1177/0269881117711708

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