TNF-α increases IDO | BioMindmap.com

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TNF-α increases Indoleamine 2,3-Dioxygenase

5.0 ValidityScore

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Proofs

2017

Publications Review

Anti-inflammatory treatment for major depressive disorder: implications for patients with an elevated immune profile and non-responders to standard antidepressant therapy
Cristina M Moriguchi-Jeckel, Erik FJ de Vries, Hans C Klein, Janine Doorduin, Luis Eduardo Juárez-Orozco, Paula Kopschina Feltes, Rudi AJO Dierckx
«It was hypothesized that during inflammation, pro-inflammatory cytokine such as IL-1β, IL-2, IL-6, INF-γ[IFN-γ] and TNF-α (Anderson et al., 2013; Kim et al., 2012; Myint and Kim, 2003) increase the activity of IDO and reduce the production of serotonin.»
Strong Magnitude of Effect.
#Major depressive disorder, antidepressants, microglia, neuroinflammation, pro-inflammatory cytokines
ncbi.nlm.nih.gov/pmc/articles/PMC5606303
10.1177/0269881117711708

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