Major depressive disorder increases TNF-α

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2017

Publications Review

Anti-inflammatory treatment for major depressive disorder: implications for patients with an elevated immune profile and non-responders to standard antidepressant therapy
Cristina M Moriguchi-Jeckel, Erik FJ de Vries, Hans C Klein, Janine Doorduin, Luis Eduardo Juárez-Orozco, Paula Kopschina Feltes, Rudi AJO Dierckx
«Numerous studies have indicated that MDD[Major depressive disorder] is accompanied by elevated levels of inflammatory biomarkers, such as the pro-inflammatory cytokine interleukin (IL)-1β, IL-6, IL-18, tumor necrosis factor alpha (TNF-α), interferon-gamma (INF-γ)[IFN-γ] (Alboni et al., 2010; Dowlati et al., 2010; Hasler, 2010; Krogh et al., 2014; Loftis et al., 2010; Maes, 2011; Messay et al., 2012; Najjar et al., 2013; Pace and Miller, 2009; Raison and Miller, 2011; Rawdin et al., 2013; Steiner et al., 2011; Sukoff Rizzo et al., 2012; Zunszain et al., 2011) and the acute phase proteins such as C-reactive protein (CRP) (Jokela et al., 2015; Valkanova et al., 2013) Munzer et al. (2013) even suggested that, besides, for example, stress hormone and psychopathological measures, cytokines may serve as biomarkers for individualized treatment of depression (Munzer et al., 2013).»
Organism: Mammals
Strong Magnitude of Effect.
#Major depressive disorder, antidepressants, microglia, neuroinflammation, pro-inflammatory cytokines
ncbi.nlm.nih.gov/pmc/articles/PMC5606303
10.1177/0269881117711708

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