Doxycycline
may decrease
Lung injury
(BioMindmap Proof Quality is Low.)
Doxycycline
may decrease
Lung injury
(BioMindmap Proof Quality is Low.)
1.2
ValidityScore
Valid or Invalid?
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2012Rodents
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Chow VT, Narasaraju T, Ng HH, Phoon MC, Seet JE, Sim MK -
«Amelioration of lung injury was further supported by the decreased protein levels of both T1-α and thrombomodulin in the BALF of infected animals treated with DOX (20 mg/kg), indicating diminished damage of the alveolar-capillary barrier (Fig. 4B and C). Interestingly, the 60 mg/kg of DOX treatment group did not exhibit T1-α and thrombomodulin reduction, despite the significantly improved lung pathology. »
- Dose: DOX (20 mg/kg)
- Organism: Mouse / Rat (Rodents)
- Strong Magnitude of Effect.
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#Acute Lung Injury / complications, Acute Lung Injury / enzymology, Acute Lung Injury / prevention &, Animals, Anti-Bacterial Agents / pharmacology, Blotting, Doxycycline / pharmacology*, Female, H H Ng, H3N2 Subtype*, Humans, Inbred BALB C, Influenza A Virus, Lung / drug effects, Lung / metabolism, Lung / virology, MEDLINE, Matrix Metalloproteinase 2 / genetics, Matrix Metalloproteinase 2 / metabolism, Matrix Metalloproteinase 9 / genetics, Matrix Metalloproteinase 9 / metabolism, Membrane Glycoproteins / genetics, Membrane Glycoproteins / metabolism, Mice, NCBI, NIH, NLM, National Center for Biotechnology Information, National Institutes of Health, National Library of Medicine, Neutrophil Infiltration / drug effects, Non-U.S. Gov', Orthomyxoviridae Infections / complications*, Peroxidase / metabolism, PubMed Abstract, Research Support, Reverse Transcriptase Polymerase Chain Reaction, T Narasaraju, Thrombomodulin / genetics, Thrombomodulin / metabolism, Vincent T Chow, Western, control*, doi:10.1016/j.yexmp.2012.03.003, pmid:22421441more... -
ranked
added it
1 year ago
on Nov 30, 2021