Lung injury
decreases
IL-10
(BioMindmap Proof Quality is Low.)
Lung injury
decreases
IL-10
(BioMindmap Proof Quality is Low.)
2.1
ValidityScore
Valid or Invalid?
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2011Rodents
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Albaiceta GM, Astudillo A, Batalla-Solís E, Fernández-García MS, Fueyo A, García-Prieto E, González-López A, López-Vázquez A, Taboada F -
«Regarding Th2 cytokines, there were no significant changes in IL-4 (Fig. 2E, P = 0.2 in ANOVA). However, IL-10 (Fig. 2F) decreased in mice submitted to high-pressure ventilation (lung injury) (P < 0.05 in ANOVA, P = 0.001 in post hoc test compared with baseline). This decrease was also significant in the repair phase (P = 0.001) and after prolonged low-pressure ventilation (P = 0.008).»
- Organism: Mouse / Rat (Rodents)
- Strong Magnitude of Effect.
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#Adrián González-López, Airway Remodeling*, Animals, Aurora Astudillo, Bronchoalveolar Lavage Fluid / cytology, Cell Proliferation / drug effects, Cells, Chemokine CXCL2 / analysis, Chemokine CXCL2 / biosynthesis, Collagen / analysis, Collagen / biosynthesis, Continuous Positive Airway Pressure / adverse effects, Cultured, Doxycycline / pharmacology, Enzyme-Linked Immunosorbent Assay, Guillermo M Albaiceta, Humans, Inbred Strains, Inflammation / complications, Inflammation / metabolism*, Inflammation / pathology, Interleukin-10 / analysis, Interleukin-10 / biosynthesis, Lung* / metabolism, Lung* / pathology, MEDLINE, Matrix Metalloproteinase 2 / analysis, Matrix Metalloproteinase 2 / biosynthesis, Matrix Metalloproteinase 9 / analysis, Matrix Metalloproteinase 9 / biosynthesis, Matrix Metalloproteinase Inhibitors, Mechanical / adverse effects, Mice, NCBI, NIH, NLM, National Center for Biotechnology Information, National Institutes of Health, National Library of Medicine, Non-U.S. Gov', PubMed Abstract, Research Support, Respiratory Distress Syndrome / complications, Respiratory Distress Syndrome / metabolism*, Respiratory Distress Syndrome / pathology, Tumor Necrosis Factor-alpha / analysis, Tumor Necrosis Factor-alpha / biosynthesis, Ventilator-Induced Lung Injury / complications, Ventilator-Induced Lung Injury / metabolism*, Ventilator-Induced Lung Injury / pathology, Ventilators, doi:10.1152/ajplung.00010.2011, pmid:21743031more... -
ranked
added it
8 months ago
on Nov 30, 2021